KMID : 0191120230380220175
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Journal of Korean Medical Science 2023 Volume.38 No. 22 p.175 ~ p.175
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Within-Host Evolution of SARS-CoV-2 in a B-Cell Depleted Patient With Successful Treatment
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Baek Yae-Jee
Park Gemma Choi Jun-Yong Kim Eun-Jin Bryan Inho Kim Gwack Jin Jung Ji-Ye
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Abstract
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Prolonged viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised host is a challenge as the treatment and infection control for chronic coronavirus disease 2019 infection is not well established and there is a potential risk of new variants emerging. A 48-year-old woman who underwent chemotherapy, including rituximab and steroid, had reactivation of SARS-CoV-2 68 days after the virus was first detected. She successfully recovered after receiving convalescent plasma and intravenous immunoglobulin. Genomic analysis demonstrated that viruses collected from the nasopharyngeal specimens at day 0 and day 68 had 18 different nucleotide mutations, implying within-host evolution after in-depth epidemiologic investigation.
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KEYWORD
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Coronavirus Disease 2019, Immunodeficiency, SARS-CoV-2, Within-Host Evolution
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